Phototherapy cell activator
THERMALIGHT
After three years of research and development, THERMALIGHT® has become a byword for evolution. It is a new breakthrough in the field of medical aesthetic treatments for facial regeneration and body remodelling. This device consists of the simultaneous combination of two systems that concentrate energy in the area to be treated.
THERMALRIGHT® generates a retracting effect on the tissue, firming it up and fighting flaccidity and stretch marks through the stimulation of collagen and elastin. On the other hand, the firmness and softness of the skin improve generating an integral effect to the treatment.
What is the effect of intense light for rejuvenation?
Cells, as they age, slow down the production of ADP and the passage to ATP is diminished; light "normalizes" this process. It facilitates the passage of ADP to ATP in the mitochondria, ATP is the energy used by the organism. It also favors the production of fibroblasts, which are the ones that produce collagen. Collagen prevents dehydration that occurs during aging precisely because of its decrease. It aligns the fibroblasts in wounds and micro-wounds, small "fractures" of the skin normally occur (pulls, scratches, bruises, etc.) that can leave small scars when healing, the alignment of fibroblasts means that with less quantity, greater tension is achieved and the "scar" is smoother.
The increase in microcirculation favors the supply of nutrients and the elimination of waste substances from the areas. It has an anti-inflammatory and anti-edematous effect. Cell mitosis (division) is accelerated if it is slowed down, as it happens in aging, until it normalizes. This makes the skin thinner less (aging effect)
At some wavelengths, a beneficial effect on acne has been shown by interfering with the proliferation of the causative germ, cutibacterium acnes (formerly called propionicbacterium acnes).
We got:
- Activation of cell metabolism thanks to the normalization of ATP synthesis in cell mitochondria.
- Due to the heat released by the absorption of light in the melanocytes of the epidermis, activate the synthesis of heat shock proteins that enhance the creation of collagen fibers and increase the metabolic rate as well as the supply of nutrients, drainage and increase of oxygen in the treated area
- Homogenization of the pigmentation of the area. Due to the other two effects and the elimination of hyperpigmented melanocytes, improve until superficial melanin spots are eliminated.
Action mechanism
Three effects are produced, which would be responsible for the biological effects:
Facilitates the conversion of ADP to ATP in the cellular mitochondria
The studies of Prof. Mesner show a greater activity of the fibroblast synthesizing collagen fibers.
Inside the cell there are negative charges (anions) and positive charges outside (cations) with a potential differential between -90 mV and -60 mV and is maintained thanks to its permeability and the sodium pump. The bioelectric effect produces an ionic normalization on both sides of the membrane.
The photoelectric activity occurs on the cell membrane, repolarizing it and increasing its excitation threshold, which is why it also has an analgesic action.
M. Raattemeyer and F. A. Popp carried out in 1981 an investigation on the ultraweak emission of photons by living cells, and that it is not bioluminescence, and that its origin could be DNA
At present there is sufficient scientific evidence that demonstrates cellular communication through electromagnetic radiation, that is, electromagnetic bioinformation. Cells emit low intensity light, ultraweak emissions of photons, biophotons, at constant specific rates. In addition, photonic radiation would be the conductive base of biologically important information in all living beings. Light plays a fundamental role in molecular processes, exciting molecules and modifying their energy levels from activated electronic states that involve the release and exchange of photons. This exchange of light is what makes biochemical reactions possible, so in addition to cellular metabolic processes, the exchange and transfer of information via biophotons should also be included as essential features of life.
Anti-inflammatory, anti-edematous, trophic, healing, analgesic, sedative, antiviral, increased microcirculation by paralyzing the opening precapillary sphincter.
Treatments to make
Thermal damage to the dermis induces the activation of fibroblasts, with the consequent formation of neocollagen.
The synthesis and reorganization of type I and III collagen fibers, while the elastic fibers, although in smaller quantity, are more ordered. The wavelengths that best achieve these effects are in the 515 range. Longer wavelengths are absorbed by water in the dermis, triggering a cytokine-mediated reaction that stimulates neocollagen synthesis. The shorter wavelengths are absorbed by melanin and oxyhemoglobin present in pigmentation and telangiectasias associated with the aging process. Therefore, all the visible elements of aging (fine wrinkles, laxity, telangiectasias, irregular pigmentation) are improved with a lower rate of adverse effects and faster recovery.
Intense Light has been shown to be an effective treatment for telangiectasias and, to a lesser extent, background erythema and papules in patients with erythemato-angiectatic rosacea. Intense Light systems can be a useful additional tool for the treatment of granulomatous rosacea, since the reduction of the vascular component allows a decrease in dermal inflammation.
Intense Light is considered a non-invasive and rapid technique that avoids the prolonged use of drugs, bacterial resistance and associated adverse effects, although its efficacy as monotherapy remains a controversial issue. Three mechanisms of action seem to act during treatment with Intense light:
The treatment induces a selective photothermolysis of the blood vessels that feed the sebaceous glands (with Hemoglobin as a chromophore), which leads to a decrease in the size of the glands and a lower rate of sebum excretion.
Photodynamic effect. Cutibacterium acnes produces porphyrins (especially protoporphyrin IX) that act as chromophores with absorption peaks from 415 to 655 nm. These wavelengths are absorbed by porphyrins, releasing free radicals with bactericidal effects and, in addition, anti-inflammatory cytokines, such as growth factor (TGF).
Thermalight by Thermafine
Photodynamic effect. Cutibacterium acnes produces porphyrins (especially protoporphyrin IX) that act as chromophores with absorption peaks from 415 to 655 nm. These wavelengths are absorbed by porphyrins, releasing free radicals with bactericidal effects and, in addition, anti-inflammatory cytokines, such as growth factor (TGF).
The treatment induces a selective photothermolysis of the blood vessels that feed the sebaceous glands (with Hemoglobin as a chromophore), which leads to a decrease in the size of the glands and a lower rate of sebum excretion.
Filters for the application of the different treatments
Square filter 550-1200 nm
Photorejuvenation treatment, vascular treatment and treatment for spots and small wrinkles.
Elongated filter 690-1200 nm
Treatment to lighten skin (small spots) and acne.
Elongated filter 610 -1200 nm
Acne treatment.
Applicator without filter 550-1200 nm
Photorejuvenation, vascular, spots, telangiectasia and small wrinkles treatments.
Exclusion criteria
Before carrying out a treatment, the following indications must be observed to prevent adverse skin reactions.
01.
Do not sunbathe or perform UVA sessions before treatment to avoid increasing skin pigmentation and making it easier to produce a burn.
02.
Treat only on intact skin, not on open wounds. This also implies not treating after chemical and/or physical peels (dermabrasion).
03.
Do not treat, under any circumstances, on tattoos or micropigmentation of the lips or eyebrows, it can cause burns and/or change the pigmentation of the tattoo or micropigmentation.
04.
Do not treat pregnant women.
05.
Do not treat pigmented lesions (moles, nevus…)
06.
Caution on epileptic people since the possible tension/fear and the use of Intense Light can trigger an attack.
07.
7. Do not treat people who are undergoing treatment where photosensitizing products are used, even 6 months after the end of treatment (Acne treatments with Roacutan®), to avoid photosensitization reactions: antipsychotic drugs, antidepressants, steroidal anti-inflammatory drugs, antimicrobial, antiparasitic.
LITERATURE
A retrospective study of the efficacy of intense pulsed light delivered by the Lacrystim® for meibomian gland dysfunction therapy -Marie Caroline Trone1,2*, Thibaud Garcin1,2, Edouard Ollier3,4, Gilles Thuret1,2 and Philippe Gain1,2
- Therapeutic Effect of Intense Pulsed Light (IPL) Combined with Meibomian Gland Expression (MGX) on Meibomian Gland Dysfunction (MGD) Shanshan Wei, Xiaotong Ren, Yuexin Wang, Yilin Chou, and Xuemin Li
- Analysis of Cytokine Levels in Tears and Clinical Correlations After Intense Pulsed Light Treating Meibomian Gland Dysfunction – LIU, R et al. – American Journal of Ophthalmology (2017).
- Treatment of ocular rosacea – Edward Wladis et al. – Survey of Ophthalmology (2018), Vol. 63.
- Improved telangiectasia and reduced recurrence rate of rosacea after treatment with 540 nm-wavelength intense pulsed light: A prospective randomized controlled trial with a 2-year follow-up – Luo,Y. et al. – Experimental and Therapeutic Medicine (2020), Vol. 19.
- Therapeutic Effect of Intense Pulsed Light on Ocular Demodicosis – Zhang, X., et al. – Current Eye Research 2019, Vol. 3.
- Intense Pulsed Light Therapy for Patients with Meibomian Gland Dysfunction and Ocular Demodex Infestation – Cheng et al. – Current Medical Sciences (2019), Vol. 39.
- Long-term effects of intense pulsed light treatment on the ocular surface in patients with rosacea-associated meibomian gland dysfunction – Seo Kyoung Yul et al. – Contact Lens and Anterior
Eye (2018), Vol. 41. - TFOS DEWS II Tear Film Report – Willcox Mark et al. – The Ocular Surface (2017), Vol. 15.
- Intense Pulsed Light for the Treatment of Dry Eye Owing to Meibomian Gland Dysfunction – Vigo, L. et al. – Journal of Visualized Experiment (2019), N°146.
- Meibum Expressibility Improvement as a Therapeutic Target of Intense Pulsed Light Treatment in Meibomian Gland Dysfunction and Its Association with Tear Inflammatory Cytokines – Choi,
M. et al. – Scientific Reports (2019), Vol. 9. - Multicenter Study of Intense Pulsed Light Therapy for Patients with Refractory Meibomian Gland Dysfunction – Reiko Arita, et al. – Cornea Volume 37, Number 12, December 2018.
- Rosacea: Molecular Mechanisms and Management of a Chronic Cutaneous Inflammatory Condition – Yu Ri Woo, et al. International Journal of Molecular Sciences, September 2016.